Cart
sales@molnova.com
Chalcone 4 hydrate
CAS No. 1202866-96-3
Chalcone 4 hydrate( —— )
Catalog No. M10740 CAS No. 1202866-96-3
Chalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
|
| 5MG | 404 | Get Quote |
|
| 10MG | 593 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1251 | Get Quote |
|
| 100MG | 1692 | Get Quote |
|
| 500MG | 3402 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameChalcone 4 hydrate
-
NoteResearch use only, not for human use.
-
Brief DescriptionChalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
-
DescriptionChalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM; shows no activities for CCL5 and CXCL8 chemokines; inhibits calcium responses mediated by CXCR4 and prevents CXCR4 internalization; blocks chemotaxis of human peripheral blood lymphocytes ex vivo, shows activity in vivo in mouse model of allergic eosinophilic airway inflammation.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetChemokine Receptor
-
RecptorChemokine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1202866-96-3
-
Formula Weight306.74
-
Molecular FormulaC16H15ClO4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CC=C(Cl)C=C1)/C=C/C2=CC=C(O)C(OC)=C2.O.[F,Cl,Br,I]
-
Chemical Name(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gasparik V, et al. ACS Med Chem Lett. 2011 Dec 9;3(1):10-4.
2. Hachet-Haas M, et al. J Biol Chem. 2008 Aug 22;283(34):23189-99.
molnova catalog
related products
-
GSK-2239633
GSK-2239633 is a potent, selective, allosteric CCR4 antagonist with pIC50 of 7.96.
-
JNJ-27141491
A potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
-
INCB-3344
A potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively.
